解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科，口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学，全科和内科
医学，法律
医学，研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学，核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学，临床
abstract：:We have examined the number of X-linked loci specifically required only during oogenesis. Complementation analyses among female-sterile (fs) mutations obtained in two mutagenesis screens--GANS' and MOHLER's--indicate that any fs locus represented by two or more mutant alleles in GANS' collection are usually present in...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:A laboratory strain of Drosophila pseudoobscura (L116) is studied that, when crossed to sex-ratio homozygous females, produces sons that exhibit varying levels of the male sex-ratio (msr) phenotype. The msr phenotype occurs only in sex-ratio males and is due to the production of a high frequency of nullo-XY sperm. The...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：:We examined linkage relationships for RecBC-mediated recombination in lytic cycle crosses of lambda phages bearing two cohesive end sites (cos) oriented in the same direction. The relationships obtained imply that a given recombinant tends to be packaged from the cos site that is the nearer one to the right of the exc...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：:The homozygosity of a population will be influenced by any recent change in the population size. The "homozygosity test" of the neutral mutation hypothesis might also be influenced by a population change. A computer simulation method is described that establishes the significance levels of observed homozygosities afte...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:DNA extracts of several rosy-mutation-bearing strains were associated with large insertions and deletions in a defined region of the molecular map believed to include the rosy locus DNA. Large-scale, intragenic mapping experiments were carried out that localized these mutations within the boundaries of the previously ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:Sequence divergence among the mitochondrial (mt) DNA of nine Lycopersicon and two closely related Solanum species was estimated using the shared fragment method. A portion of each mt genome was highlighted by probing total DNA with a series of plasmid clones containing mt-specific DNA fragments from Lycopersicon penne...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:We have analyzed two variants of Drosophila melanogaster (RS and RE) which lead to the dual phenotype of elevated DDC activity and increased resistance to dietary alpha-methyldopa relative to Oregon-R controls. Both phenotypes show tight genetic linkage to the dopa decarboxylase, Ddc, and l(2)amd genes (i.e., less tha...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-02-01 00:00:00
abstract：:Three hundred and fifteen kilobases of DNA from the rosy-Ace region on chromosome 3R of D. melanogaster have previously been cloned and extensively characterized. We describe the isolation of nine new deficiency mutants that break within the 315-kb interval. The position of these breakpoints on the DNA map was determi...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:The relationship between multidimensional form of the adult mouse mandible and body size is examined from an ontogenetic perspective. The origin and ontogeny of phenotypic correlations are described in terms of genetic and environmental covariance patterns between adult skeletal morphology and growth in body weight. D...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
abstract：:The ability of autonomously replicating plasmids to recombine in mammalian cells was investigated. Two deletion plasmids of the eukaryotic-prokaryotic shuttle vector pSV2neo were cotransfected into transformed monkey COS cells. Examination of the low molecular weight DNA isolated after 48 hr of incubation revealed tha...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-10-01 00:00:00
abstract：:There are two common alleles at the Amylase-2 locus in populations of Gammarus palustris, the salt marsh amphipod. Intensive sampling of individuals from two localities at Jamaica Bay revealed a consistent pattern of heterozygote deficiency.-Five possible sources of heterozygote deficiency were examined in this study....
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-10-01 00:00:00
abstract：:Previous mathematical analyses of mutation-selection balance for metric traits assume that selection acts on the relevant loci only through the character(s) under study. Thus, they implicitly assume that all of the relevant mutation and selection parameters are estimable. A more realistic analysis must recognize that ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：:The identification of a second structural gene mutation at the feline arylsulfatase B locus (MPS VIb) provided the opportunity to investigate the expression of allelism by characterization of the residual enzymatic activity in feline mucopolysaccharidosis VI, an animal analogue of human Maroteaux-Lamy syndrome. Mating...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-08-01 00:00:00
abstract：:Samples of mtDNA isolated from each of 92 lizards representing all color pattern classes of Cnemidophorus tesselatus and two populations of C. tigris marmoratus were digested with the restriction endonucleases MboI, TaqI, RsaI and MspI. The mtDNA fragment sizes were compared after radioactive labeling and gel electrop...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-08-01 00:00:00
abstract：:The distribution of the number of HLA haplotypes shared by sibs affected with the same HLA-linked disease can be used to obtain information on the genetics of the disease. Since the inception of the use of sib-pair methods for the analysis of the HLA-associated diseases, the question has been raised of how to include ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:Thirteen of 14 temperature-sensitive mutants deficient in successive steps of mitotic chromosome transmission (cdc2, 4, 5, 6, 7, 8, 9, 13, 14, 15, 16, 17 and 20) from spindle pole body separation to a late stage of nuclear division exhibited a dramatic increase in the frequency of chromosome loss and/or mitotic recomb...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:A radiation-induced translocation, T(IIR----IIIL), has been shown to be nonreciprocal and to have most of IIR, including its terminus, attached uninverted to the terminus of IIIL.--Progeny with the IIR segment in duplicate, obtained from crosses of T(IIR----IIIL) to strains with a standard genome, were unstable at mit...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:A two-locus model is used to analyze the effectiveness of a mixture of insecticides in delaying resistance, compared to the use of the insecticides singly. The effects of factors such as recombination, effective dominance, initial value of allele frequencies and initial value of linkage disequilibrium are considered. ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-04-01 00:00:00
abstract：:In somatic cells of Drosophila, the ratio of X chromosomes to autosomes (X:A ratio) determines sex and dosage compensation. The present paper addresses the question of whether germ cells also use the X:A ratio for sex determination and dosage compensation. Triploid female embryos were generated which, through the loss...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:A model of the evolution of a transposable element family in a Mendelian host population is proposed that incorporates heritable phenotypic mutations in the elements. The temporal behavior of the numbers of mutant and wild-type elements is studied, and the expected extinction time of the transposable element family is...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-02-01 00:00:00
abstract：:Two Podospora mutants carrying mutations modE and modF were persumed to be quiescent defective, because, when grown under glucose limitation, they differed from the wild-type strain in an excess of dry weight production and a reduction of cell survival. New insight on the action of modE and modF mutations was provided...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Male mating success as a function of genotype is an important fitness component. It can be studied in wild populations, in species for which a given group of progeny has exactly one father, by determining genotypes of wildcaught mothers and of sufficient numbers of their progeny. Here, we study male mating success as ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:In lytic cycle crosses with Red-Gam-lambda phage, particles were examined that had undergone an Int-mediated exchange. It was assumed that this exchange dimerized the circular lambda, making it packageable. Among these Int-mediated recombinants, particles were identified that had, in addition, enjoyed a close double e...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:Selection coefficients and segregation parameters have been estimated in 18 randomly chosen lines carrying wild X chromosomes on the cn bw genetic background. Each line was studied in replicated crosses of four types, with approximately 100 replications per line per cross. Crosses in which male X chromosomes differed ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:The recombination frequency as influenced by five independent recessive ds genes was measured on three segments of different chromosomes of rice, Oryza sativa L. Each ds gene in the homozygous condition resulted in an almost equally reduced recombination frequency in the three segments. When the mean reduction in reco...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：:We have analyzed the 2E1-3A1 area of the X chromosome with special attention to loci related to embryogenesis. Published maps indicate that this chromosomal segment contains ten bands. Our genetic analysis has identified 11 complementation groups: one recessive visible (prune), two female steriles and eight lethals. O...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：:Mutants at the snail locus are zygotically acting embryonic lethals that affect dorsoventral patterning. A comparison of seven mutant alleles shows considerable variation in expressivity and a graded effect along the dorsoventral axis: more extreme alleles result in the abnormal development of the dorsally derived ect...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:The long-term population genetics of multigene families is influenced by several biased and unbiased mechanisms of nonreciprocal exchanges (gene conversion, unequal exchanges, transposition) between member genes, often distributed on several chromosomes. These mechanisms cause fluctuations in the copy number of varian...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:The effect of nonhomologous DNA sequences at one or both sides of short genetic intervals on recombination within that interval was investigated, using an interplasmidic recombination system in Escherichia coli K-12. The recombining plasmids were derivatives of pBR322 and pACYC184, which share a 1330-nucleotide sequen...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:When ultraviolet-irradiated bacteriophage T4 is assayed at plating temperatures ranging from 20 degrees to 40 degrees, its survival increases at the higher temperatures. This "thermal rescue" requires an intact WXY system but not the denV pyrimidine dimer excision system. Mutation rates decrease with increasing temper...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：:Linkage relationships of nine enzyme loci; aconitase (Acon ), esterase (Est), glucosephosphate isomerase A and B ( Gpi), glycerate-2-dehydrogenase (G2dh), malic enzyme (Me ), phosphoglycerate kinase (Pgk), phosphoglucomutase (Pgm ) and superoxide dismutase (Sod), were investigated in sunfishes (Lepomis, Centrarchidae)...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：:Sxl appears to head a regulatory gene hierarchy that controls Drosophila sexual dimorphism in response to the X chromosome/autosome balance. Only XXAA cells normally have Sxl(+) activity. It maintains both the female morphogenetic sequence and a level of X-linked dosage-compensated gene expression compatible with dipl...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：:The percentage of crossovers is consistently higher in plants hypoploid for six B-A translocations when crossed as males than when crossed as females; in most instances, this excess of male crossing over exceeds that found in control crosses (involving normal chromosomes). Thus, there seems to be something about the h...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
abstract：:Sixteen inbred or partially inbred strains of rabbits were investigated for electrophoretic and quantitative variations of alpha-1-antitrypsin (A-1-AT). We found interindividual differences in the electrophoretic A-1-AT patterns as well as quantitative differences in the concentrations of A-1-AT and the serum trypsin-...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：:Studies of multifactorial inheritance in man have ignored nonadditive gene action or attributed it entirely to dominance. Reanalyses of dermatoglyphic data on monozygotic and dizygotic twins, siblings and parents and offspring suggest that a substantial proportion of variation in total finger pattern intensity is due ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：:The effect of full-sib inbreeding on competitive male-mating ability (CImale symbol) in Drosophila melanogaster was investigated in two experiments. In the first, five inbred lines (with reserves) were assessed up to 18 generations. Linear inbreeding depression, of 5.9% per 10% increase in homozygosity, was observed. ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：:Two protocols are presented that allow the selection of mutations mapping to micronuclear chromosome 5 in Tetrahymena thermophilia. One protocol involves crossing mutagenized diploid cells directly to a strain nullisomic for chromosome 5 and screening the monosomic progeny for a mutant phenotype. The second protocol f...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:The region containing subdivisions 93C, 93D and 93E on chromosome 3 of Drosophila melanogaster has been screened for visible and lethal mutations. Treatment with three mutagens, gamma irradiation, ethyl methanesulfonate and diepoxybutane, has produced mutations that fall into 20 complementation groups, including the p...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：:Recessive mutant alleles at the autosomal dpy-21 locus of C. elegans cause a dumpy phenotype in XX animals but not in XO animals. This dumpy phenotype is characteristic of X chromosome aneuploids with higher than normal X to autosome ratios and is proposed to result from overexpression of X-linked genes. We have isola...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:The mutation rates of specific loci and chromosome regions were estimated for two types of dysgenic hybrid males. These came from crosses between P or Q males and M females in the P-M system of hybrid dysgenesis. The M X P hybrids were the more mutable for each of the loci and chromosome regions tested. The Beadex loc...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
